Well, as far as i know, cracks and no-cd loaders and other apps like this, are made based on a trojan backdoor code that's harmless to the computer or OS, it just does what it's supposed to do, crack the damn thing.
This being said, its pretty normal to have your antivirus shout like mad that you have a virus.
I simply dont understand why you guys use antivirus software that simply dont do anything. If your ment to catch a cold, you'll catch it anyways, regardless of how many aspirins you take.
The best antivirus is the brains of the computer user. If you dont download porn from suspicious websites, files from public torrent sites or other stuff like that, you should be fine.